Ski complex

The Ski complex is a multi-protein complex involved in the 3' end degradation of messenger RNAs.^[1] The complex consists of three main proteins, the RNA helicase Ski2 and the proteins Ski3 and Ski8. In yeast, the complex guides RNA molecules to the exosome complex for degradation via a fourth protein, called Ski7, which contains a GTPase-like protein. ^[2]

See also

• TRAMP complex
• Non-stop decay
• Nonsense mediated decay

References

1. ^ Araki et al.; Takahashi, S; Kobayashi, T; Kajiho, H; Hoshino, S; Katada, T (2001). "Ski7p G protein interacts with the exosome and the Ski complex for 3′-to-5′ mRNA decay in yeast". EMBO Journal 20 (17): 4684–93. doi:10.1093/emboj/20.17.4684. PMC 125587. PMID 11532933. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=125587. 
2. ^ Wang et al.; Lewis, MS; Johnson, AW (2005). "Domain interactions within the Ski2/3/8 complex and between the Ski complex and Ski7p". RNA 11 (8): 1291–302. doi:10.1261/rna.2060405. PMC 1370812. PMID 16043509. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1370812.